Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection.

ABSTRACT: Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as the capacity to preserve and/or rapidly restore immune functions that promote disease resistance (immunocompetence) and control inflammation in infectious diseases as well as other causes of inflammatory stress. We gauge IR levels with two distinct peripheral blood metrics that quantify the balance between (i) CD8⁺ and CD4⁺ T-cell levels and (ii) gene expression signatures tracking longevity-associated immunocompetence and mortality-associated inflammation. Profiles of IR metrics in ~48,500 individuals collectively indicate that some persons resist degradation

SUBMITTER: Ahuja SK 

PROVIDER: S-EPMC10264401 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature