Temperature-triggered in situ forming lipid mesophase gel for local treatment of ulcerative colitis.

ABSTRACT: Ulcerative colitis is a chronic inflammatory bowel disease that strongly affects patient quality of life. Side effects of current therapies necessitate new treatment strategies that maximise the drug concentration at the site of inflammation, while minimizing systemic exposure. Capitalizing on the biocompatible and biodegradable structure of lipid mesophases, we present a temperature-triggered in situ forming lipid gel for topical treatment of colitis. We show that the gel is versatile and can host and release drugs of different polarities, including tofacitinib and tacrolimus, in a sustained manner. Further, we demonstrate its adherence to the colonic wall for at least 6 h, thus preventing leakage and improving drug bioavailability. Importantly, we find that loading known colitis treatmen

SUBMITTER: Carone M 

PROVIDER: S-EPMC10264425 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature