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Chimaeric plant-produced bluetongue virus particles as potential vaccine candidates.

ABSTRACT: Bluetongue virus (BTV) causes bluetongue disease in ruminants and sheep. The current live attenuated and inactivated vaccines available for prevention pose several risks, and there is thus a need for vaccines that are safer, economically viable, and effective against multiple circulating serotypes. This work describes the development of recombinant virus-like particle (VLP) vaccine candidates in plants, which are assembled by co-expression of the four BTV serotype 8 major structural proteins. We show that substitution of a neutralising tip domain of BTV8 VP2 with that of BTV1 VP2 resulted in the assembly of VLPs that stimulated serotype-specific antibodies as well as virus-specific neutralising antibodies.

SUBMITTER: Gwynn A

PROVIDER: S-EPMC10264491 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Chimaeric plant-produced bluetongue virus particles as potential vaccine candidates.

Gwynn A A Mbewana S S Lubisi B A BA Tshabalala H M HM Rybicki E P EP Meyers A E AE

Archives of virology 20230613 7

Bluetongue virus (BTV) causes bluetongue disease in ruminants and sheep. The current live attenuated and inactivated vaccines available for prevention pose several risks, and there is thus a need for vaccines that are safer, economically viable, and effective against multiple circulating serotypes. This work describes the development of recombinant virus-like particle (VLP) vaccine candidates in plants, which are assembled by co-expression of the four BTV serotype 8 major structural proteins. We ...[more]

PMID: 37310539

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