Recombinant hemagglutinin displaying on yeast reshapes congenital lymphocyte subsets to prompt optimized systemic immune protection against avian influenza infection.

ABSTRACT:

Introduction

Prophylactic vaccination is regarded as the most effective means to control avian flu infection. Currently, there is a need for a universal vaccine that provides broad and long-lasting protection against influenza virus. Meanwhile, although yeast-based vaccines have been used in clinic, studies are still required to further understand the molecular mechanism of yeast-based vaccines under physiological conditions.

Methods

We generated a yeast-based vaccine against influenza hemagglutinin (HA) of H5, H7 and H9 using surface displaying technology and evaluated the protective efficacy of chickens after exposure to H9N2 influenza virus.

Results

Oral yeast vaccine provided less clinical syndrome, reduced viral loading and alleviated airway damage significantly.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10264594 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature