Identification of serum biomarkers for necrotizing enterocolitis using aptamer-based proteomics.

ABSTRACT:

Introduction

Necrotizing enterocolitis (NEC) is a potentially fatal intestinal disease primarily affecting preterm infants. Early diagnosis of neonates with NEC is crucial to improving outcomes; however, traditional diagnostic tools remain inadequate. Biomarkers represent an opportunity to improve the speed and accuracy of diagnosis, but they are not routinely used in clinical practice.

Methods

In this study, we utilized an aptamer-based proteomic discovery assay to identify new serum biomarkers of NEC. We compared levels of serum proteins in neonates with and without NEC and identified ten differentially expressed serum proteins between these groups.

Results

We detected two proteins, C-C motif chemokine ligand 16 (CCL16) and immunoglobulin heavy constant alpha 1 and

SUBMITTER: Mackay S 

PROVIDER: S-EPMC10264655 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature