Development of innate immune memory by non-immune cells during Staphylococcus aureus infection depends on reactive oxygen species.

ABSTRACT:

Introduction

The mechanisms underlying innate immune memory (trained immunity) comprise epigenetic reprogramming of transcriptional pathways associated with alterations of intracellular metabolism. While the mechanisms of innate immune memory carried out by immune cells are well characterized, such processes in non-immune cells, are poorly understood. The opportunistic pathogen, Staphylococcus aureus, is responsible for a multitude of human diseases, including pneumonia, endocarditis and osteomyelitis, as well as animal infections, including chronic cattle mastitis that are extremely difficult to treat. An induction of innate immune memory may be considered as a therapeutic alternative to fight S. aureus infection.

Methods

In the current work, we demonstrated t

SUBMITTER: Chaumond E 

PROVIDER: S-EPMC10264681 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature