The impact of epigenetic modifications on allogeneic hematopoietic stem cell transplantation.
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ABSTRACT:
SUBMITTER: Ktena YP
PROVIDER: S-EPMC10264773 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
The impact of epigenetic modifications on allogeneic hematopoietic stem cell transplantation.
Ktena Yiouli P YP Dionysiou Margarita M Gondek Lukasz P LP Cooke Kenneth R KR
Frontiers in immunology 20230531
The field of epigenetics studies the complex processes that regulate gene expression without altering the DNA sequence itself. It is well established that epigenetic modifications are crucial to cellular homeostasis and differentiation and play a vital role in hematopoiesis and immunity. Epigenetic marks can be mitotically and/or meiotically heritable upon cell division, forming the basis of cellular memory, and have the potential to be reversed between cellular fate transitions. Hence, over the ...[more]
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