Shared genetic and environmental etiology between substance use disorders and suicidal behavior.

ABSTRACT:

Background

Previous studies have demonstrated substantial associations between substance use disorders (SUD) and suicidal behavior. The current study empirically assesses the extent to which shared genetic and/or environmental factors contribute to associations between alcohol use disorders (AUD) or drug use disorders (DUD) and suicidal behavior, including attempts and death.

Methods

The authors used Swedish national registry data, including medical, pharmacy, criminal, and death registrations, for a large cohort of twins, full siblings, and half siblings (N = 1 314 990) born 1960-1980 and followed through 2017. They conducted twin-sibling modeling of suicide attempt (SA) or suicide death (SD) with AUD and DUD to estimate genetic and environmental correlations between

SUBMITTER: Edwards AC 

PROVIDER: S-EPMC10264825 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature