Associations of striatal dopamine transporter binding with motor and non-motor symptoms in early Parkinson's disease.

ABSTRACT: Dopamine transporter (DAT) imaging is an in vivo tool to assess presynaptic dopaminergic function in the clinical practices of Parkinson's disease (PD). Current clinical practices focused on qualitatively visual interpretation of DAT imaging, whereas quantitative analyses are potentially more helpful when monitoring the progression of PD. Previous cross-sectional studies indicated certain motor and non-motor features were associated with striatal DAT binding, whereas limited data were reported in terms of the longitudinal correlation between clinical features of PD with striatal DAT binding. The purpose of our study is to clarify current and longitudinal correlations between striatal DAT binding and clinical measures. A total of 352 untreated PD individuals and 167 healthy controls with co

SUBMITTER: Yang Z 

PROVIDER: S-EPMC10264928 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature