METTL3 Mediates Epithelial-Mesenchymal Transition by Modulating FOXO1 mRNA N⁶ -Methyladenosine-Dependent YTHDF2 Binding: A Novel Mechanism of Radiation-Induced Lung Injury.

ABSTRACT: The biological roles of epithelial-mesenchymal transition (EMT) in the pathogenesis of radiation-induced lung injury (RILI) have been widely demonstrated, but the mechanisms involved have been incompletely elucidated. N⁶ -methyladenosine (m⁶ A) modification, the most abundant reversible methylation modification in eukaryotic mRNAs, plays vital roles in multiple biological processes. Whether and how m⁶ A modification participates in ionizing radiation (IR)-induced EMT and RILI remain unclear. Here, significantly increased m⁶ A levels upon IR-induced EMT are detected both in vivo and in vitro. Furthermore, upregulated methyltransferase-like 3 (METTL3) expression and downregulated α-ketoglutarate-dependent dioxygenase AlkB homolog 5 (ALKBH5) express

SUBMITTER: Feng Y 

PROVIDER: S-EPMC10265050 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature