The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis.

ABSTRACT: The role of zinc in hematopoiesis is currently unclear. Here, SLC39A10 (ZIP10) is identified as a key zinc transporter in hematopoiesis. The results show that in zebrafish, Slc39a10 is a key regulator of the response to zinc deficiency. Surprisingly, both slc39a10 mutant zebrafish and hematopoietic Slc39a10-deficient mice develop a more severe form of impaired hematopoiesis than animals lacking transferrin receptor 1, a well-characterized iron gatekeeper, indicating that zinc plays a larger role than iron in hematopoiesis, at least in early hematopoietic stem cells (HSCs). Furthermore, it is shown that loss of Slc39a10 causes zinc deficiency in fetal HSCs, which in turn leads to DNA damage, apoptosis, and G₁ cell cycle arrest. Notably, zinc supplementation largely restores colon

SUBMITTER: He X 

PROVIDER: S-EPMC10265086 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature