A rapid-crosslinking antimicrobial hydrogel with enhanced antibacterial capabilities for improving wound healing.

ABSTRACT: One of the main reasons impeding wound healing is wound infection caused by bacterial colonization with a continuous stage of inflammation. Traditional wound treatments like gauze are being replaced by tissue adhesives with strong wet tissue adhesion and biocompatibility. Herein, a fast-crosslinking hydrogel is developed to achieve both strong antimicrobial properties and excellent biocompatibility. In this study, a simple and non-toxic composite hydrogel was prepared by the Schiff base reaction between the aldehyde group of 2,3,4-trihydroxybenzaldehyde (TBA) and the amino group of ε-Poly-_L-lysine (EPL). Subsequently, a succession of experiments toward this new hydrogel including structure characterization, antimicrobial properties, cell experiment and wound healin

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10265121 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature