PD1^hi CD200^hi CD4⁺ exhausted T cell increase immunotherapy resistance and tumour progression by promoting epithelial-mesenchymal transition in bladder cancer.

ABSTRACT:

Background

Bladder cancer (BLCA) is one of the most diagnosed cancers in humans worldwide. Recently, immunotherapy has become a main treatment option for BC. However, most BLCA patients do not respond to immune checkpoint inhibitors or relapse after immunotherapy. Therefore, it is very important to identify novel biomarkers for the prediction of immunotherapy response in B patients.

Methods

Pancancer single-cell RNA sequencing (scRNA-seq) data were used to identify the clusters of CD4⁺ T cells in the tumour microenvironment (TME). The clinical significance of key CD4⁺ T-cell clusters was evaluated based on the survival data of two independent immunotherapy bladder cancer (BLCA) cohorts. We also investigated the function of key clusters of CD4⁺

SUBMITTER: Wu C 

PROVIDER: S-EPMC10265167 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature