Age-mediated gut microbiota dysbiosis promotes the loss of dendritic cells tolerance.

ABSTRACT: The old age-related loss of immune tolerance inflicts a person with a wide range of autoimmune and inflammatory diseases. Dendritic cells (DCs) are the sentinels of the immune system that maintain immune tolerance through cytokines and regulatory T-cells generation. Aging disturbs the microbial composition of the gut, causing immune system dysregulation. However, the vis-à-vis role of gut dysbiosis on DCs tolerance remains highly elusive. Consequently, we studied the influence of aging on gut dysbiosis and its impact on the loss of DC tolerance. We show that DCs generated from either the aged (DC^Old ) or gut-dysbiotic young (DC^Dysbiotic ) but not young (DC^Young ) mice exhibited loss of tolerance, as evidenced by their failure to optimally induce the generat

SUBMITTER: Bashir H 

PROVIDER: S-EPMC10265174 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature