Non-invasive and invasive measurement of skeletal muscular oxygenation during isolated limb perfusion.

ABSTRACT:

Background

Isolated limb perfusion (ILP) is a regional surgical treatment for localized metastatic disease. High doses of chemotherapeutic agents are administered within an extracorporeal circulated isolated extremity, treating the metastasis, while systemic toxicity is avoided. To our knowledge, indexed oxygen supply/demand relationship during ILP has not previously been described. Our aim was to measure and describe oxygen metabolism, specifically oxygen delivery, consumption, and extraction, in an isolated leg/arm during ILP. Also investigate whether invasive oxygenation measurement during ILP correlates and can be used interchangeable with the non-invasive method, near infrared spectroscopy (NIRS).

Methods

Data from 40 patients scheduled for ILP were included. At six tim

SUBMITTER: Corderfeldt Keiller A 

PROVIDER: S-EPMC10265298 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature