Effects of bowel cleansing on the composition of the gut microbiota in inflammatory bowel disease patients and healthy controls.

ABSTRACT:

Background

In patients with inflammatory bowel disease (IBD), Crohn's disease (CD), and ulcerative colitis (UC), numerous cases of exacerbations could be observed after colonoscopy, raising the possible pathogenetic effect of colonic microbiota alterations in IBD flare.

Objectives

We aimed to investigate the changes in the fecal microbiota composition in IBD patients influenced by the bowel preparation with sodium picosulfate.

Design

We enrolled patients with IBD undergoing bowel preparation for colonoscopy in the prospective cohort study. The control group (Con) comprised non-IBD patients who underwent colonoscopy. Clinical data, blood, and stool samples were collected before colonoscopy (timepoint A), 3 days later (timepoint B), and 4 weeks later (timepoint C).

M

SUBMITTER: Bacsur P 

PROVIDER: S-EPMC10265323 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature