Local control of bone metastasis treated with palliative radiotherapy in patients with lung cancer: An observational retrospective cohort study.

ABSTRACT: Bone metastasis is common in advanced lung cancer, with the incidence reported to be 30%, and radiotherapy (RT) is used for pain relief from bone metastasis. The present study aimed to identify factors affecting local control (LC) of bone metastasis from lung cancer and to assess the significance of moderate RT dose escalation. This was a retrospective cohort study, where LC of bone metastasis from lung cancer that had received palliative RT was reviewed. LC at RT sites was evaluated with follow-up computed tomography (CT). The influence of treatment-, cancer- and patient-related risk factors for LC was assessed. A total of 317 metastatic lesions in 210 patients with lung cancer were evaluated. The median RT dose (biologically effective dose calculated using an α/β of 10 Gy; BED10) was 39.

SUBMITTER: Makita K 

PROVIDER: S-EPMC10265332 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature