Dataset Information

Air pollution and mortality in patients with chronic obstructive pulmonary disease: a cohort study in South Korea.

ABSTRACT:

Background

Evidence on whether long-term exposure to air pollution increases the mortality risk in patients with chronic obstructive pulmonary disease (COPD) is limited.

Objectives

We aimed to investigate the associations of long-term exposure to particulate matter with diameter <10 µm (PM₁₀) and nitrogen dioxide (NO₂) with overall and disease-specific mortality in COPD patients.

Design

We conducted a nationwide retrospective cohort study of 121,423 adults ⩾40 years diagnosed with COPD during 1 January to 31 December 2009.

Methods

Exposure to PM₁₀ and NO₂ was estimated for residential location using the ordinary kriging method. We estimated the risk of overall mortality associated with 1-, 3-, and 5-years average concentrations of PM₁₀ and NO₂ using Cox proportional hazards models and disease-specific mortality using the Fine and Gray method adjusted for age, sex, income, body mass index, smoking, comorbidities, and exacerbation history.

Results

The adjusted hazard ratios (HRs) for overall mortality associated with a 10 µg/m³ increase in 1-year PM₁₀ and NO₂ exposures were 1.004 [95% confidence interval (CI) = 0.985, 1.023] and 0.993 (95% CI = 0.984, 1.002), respectively. The results were similar for 3- and 5-year exposures. For a 10-µg/m³ increase in 1-year PM₁₀ and NO₂ exposures, the adjusted HRs for chronic lower airway disease mortality were 1.068 (95% CI = 1.024, 1.113) and 1.029 (95% CI = 1.009, 1.050), respectively. In stratified analyses, exposures to PM₁₀ and NO₂ were associated with overall mortality in patients who were underweight and had a history of severe exacerbation.

Conclusion

In this large population-based study of patients with COPD, long-term PM₁₀ and NO₂ exposures were not associated with overall mortality but were associated with chronic lower airway disease mortality. PM₁₀ and NO₂ exposures were both associated with an increased risk of overall mortality, and with overall mortality in underweight individuals and those with a history of severe exacerbation.

SUBMITTER: Kang S

PROVIDER: S-EPMC10265343 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Air pollution and mortality in patients with chronic obstructive pulmonary disease: a cohort study in South Korea.

Kang Suna S Hong Yun Soo YS Park Jihwan J Kang Danbee D Kim Hyunsoo H Lee Jin J Kim Woojin W Kang Sung-Won SW Guallar Eliseo E Cho Juhee J Park Hye Yun HY

Therapeutic advances in chronic disease 20230606

<h4>Background</h4>Evidence on whether long-term exposure to air pollution increases the mortality risk in patients with chronic obstructive pulmonary disease (COPD) is limited.<h4>Objectives</h4>We aimed to investigate the associations of long-term exposure to particulate matter with diameter <10 µm (PM<sub>10</sub>) and nitrogen dioxide (NO<sub>2</sub>) with overall and disease-specific mortality in COPD patients.<h4>Design</h4>We conducted a nationwide retrospective cohort study of 121,423 ad ...[more]

PMID: 37324407

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Project description:Meniere's disease is thought to be a disorder of the inner ear function, affected by genetic and environmental factors. Several recent studies have shown that air pollution could affect middle and inner ear diseases. The purpose of this study was to investigate the relationship between the Meniere's disease occurrence and air pollution status in Korea. This study used a time-stratified case-crossover design. Hospital visit data by Meniere's disease were collected from the Korea National Health Insurance Service-National Sample Cohort (NHIS-NSC) database. Daily air pollution data for sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), ozone (O3), and particulate matter (PM10: ≤ 10 μm in diameter, and PM2.5: ≤ 2.5 μm in diameter) were collected from the National Ambient air quality Monitoring Information System (NAMIS) database. We used two-stage analysis to assess the association between degree of air pollution and the occurrence of Meniere's disease. In the first stage, region-specific analysis was conducted to estimate the odds ratios (ORs) of Meniere's disease risk associated with each air pollutant exposure by using conditional logistic regression for matched case-control sets in 16 regions. In the second stage, region-specific ORs from the first stage were combined and the pooled effect estimates were derived through fixed and random effect meta-analysis. Subgroup analysis was conducted for age, sex, seasonality, and urbanization of residence. In total, 29,646 (32.1% males and 67.9% females) Meniere's disease cases were identified from Korea NHIS-NSC database between 2008 and 2015. Overall, SO2, NO2, CO, and PM10 showed significant correlation with Meniere's disease risk at immediate lags, and weaker correlation at delayed lags, whereas O3 showed slightly negative correlation at the immediate lag (lag0) and PM2.5 did not show strong correlation (SO2: 1.04 [95% confidence interval: 1.01, 1.06]; NO2: 1.08 [1.06, 1.11]; CO: 1.04 [1.02, 1.06]; O3: 0.96 [0.93, 0.99]: statistically significant ORs at lag0 are listed). These positive and negative associations between Meniere's disease and each air pollutant were generally stronger in the age of 40-64, female, summer (June-August) season, and urban subgroups. Our results showed that hospital visits for Meniere's disease were associated with the measured concentrations of ambient air pollutants SO2, NO2, CO, and PM10. Further studies are required to confirm these associations and find their mechanisms.

Dataset Information

Air pollution and mortality in patients with chronic obstructive pulmonary disease: a cohort study in South Korea.

Background

Objectives

Design

Methods

Results

Conclusion

Publications

Air pollution and mortality in patients with chronic obstructive pulmonary disease: a cohort study in South Korea.

Similar Datasets

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