Predialysis trajectories of estimated GFR and concurrent trends of Chronic Kidney Disease-relevant biomarkers

ABSTRACT:

Background:

The glomerular filtration rate (GFR) decline varies in patients with advanced chronic kidney disease (CKD), and the concurrent changes in CKD-related biomarkers are unclear.

Objectives:

This study aimed to examine the changes in CKD-related biomarkers along with the kidney function decline in various GFR trajectory groups.

Design:

This study was a longitudinal cohort study originated from the pre-end-stage renal disease (pre-ESRD) care program in a single tertiary center between 2006 and 2019.

Methods:

We adopted a group-based trajectory model to categorize CKD patients into three trajectories according to estimated glomerular filtration rate (eGFR) changes. A repeated-measures linear mixed model was used to estimate the concurrent biomarker

SUBMITTER:  

PROVIDER: S-EPMC10265358 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature