The effects of hydrocortisone and yohimbine on human behavior in approach-avoidance conflicts.

ABSTRACT:

Rationale

Balancing approach of positive and avoidance of negative stimuli is essential when faced with approach-avoidance conflicts, e.g., situations with both positive and negative outcomes. This balance is disturbed in several mental disorders, e.g., excessive avoidance in anxiety disorders, and heightened approach in substance use disorders. Since stress is assumed to impact these disorders' etiology and maintenance, it seems crucial to understand how stress influences behavior in approach-avoidance conflicts. Indeed, some studies suggested altered approach-avoidance behavior under acute stress, but the mechanism underlying these effects is unknown.

Objectives

Investigate how the pharmacological manipulation of major stress mediators (cortisol and noradrenaline) influenc

SUBMITTER: Fricke K 

PROVIDER: S-EPMC10265560 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature