Assessing Differential Particle Deformability under Microfluidic Flow Conditions.

ABSTRACT: Assessing the mechanical behavior of nano- and micron-scale particles with complex shapes is fundamental in drug delivery. Although different techniques are available to quantify the bulk stiffness in static conditions, there is still uncertainty in assessing particle deformability in dynamic conditions. Here, a microfluidic chip is designed, engineered, and validated as a platform to assess the mechanical behavior of fluid-borne particles. Specifically, potassium hydroxide (KOH) wet etching was used to realize a channel incorporating a series of micropillars (filtering modules) with different geometries and openings, acting as microfilters in the direction of the flow. These filtering modules were designed with progressively decreasing openings, ranging in size from about 5 down to 1 μm.

SUBMITTER: Miali ME 

PROVIDER: S-EPMC10265569 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature