Sex differences in olfactory cortex neuronal loss in aging.

ABSTRACT:

Introduction

Aging plays a major role in neurodegenerative disorders such as Alzheimer's disease, and impacts neuronal loss. Olfactory dysfunction can be an early alteration heralding the presence of a neurodegenerative disorder in aging. Studying alterations in olfaction-related brain regions might help detection of neurodegenerative diseases at an earlier stage as well as protect individuals from any danger caused by loss of sense of smell.

Objective

To assess the effect of age and sex on olfactory cortex volume in cognitively healthy participants.

Method

Neurologically healthy participants were divided in three groups based on their age: young (20-35 years; n = 53), middle-aged (36-65 years; n = 66) and older (66-85 years; n = 95). T1-weighted

SUBMITTER: Alotaibi MM 

PROVIDER: S-EPMC10265738 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature