Stress granule activation attenuates lipopolysaccharide-induced cardiomyocyte dysfunction.

ABSTRACT:

Background

Sepsis is the leading cause of death in intensive care units. Sepsis-induced myocardial dysfunction, one of the most serious complications of sepsis, is associated with higher mortality rates. As the pathogenesis of sepsis-induced cardiomyopathy has not been fully elucidated, there is no specific therapeutic approach. Stress granules (SG) are cytoplasmic membrane-less compartments that form in response to cellular stress and play important roles in various cell signaling pathways. The role of SG in sepsis-induced myocardial dysfunction has not been determined. Therefore, this study aimed to determine the effects of SG activation in septic cardiomyocytes (CMs).

Methods

Neonatal CMs were treated with lipopolysaccharide (LPS). SG activation was visualized by immunofl

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10265778 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature