Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model.

ABSTRACT:

Background

Autism Spectrum Disorders (ASD) patients experience disturbed nociception in the form of either hyposensitivity to pain or allodynia. A substantial amount of processing of somatosensory and nociceptive stimulus takes place in the dorsal spinal cord. However, many of these circuits are not very well understood in the context of nociceptive processing in ASD.

Methods

We have used a Shank2^-/- mouse model, which displays a set of phenotypes reminiscent of ASD, and performed behavioural and microscopic analysis to investigate the role of dorsal horn circuitry in nociceptive processing of ASD.

Results

We determined that Shank2^-/- mice display increased sensitivity to formalin pain and thermal preference, but a sensory specific mechanical all

SUBMITTER: Olde Heuvel F 

PROVIDER: S-EPMC10265811 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature