Participant retention in paediatric randomised controlled trials published in six major journals 2015-2019: systematic review and meta-analysis.

ABSTRACT:

Background

The factors which influence participant retention in paediatric randomised controlled trials are under-researched. Retention may be more challenging due to child developmental stages, involving additional participants, and proxy-reporting of outcomes. This systematic review and meta-analysis explores the factors which may influence retention in paediatric trials.

Methods

Using the MEDLINE database, paediatric randomised controlled trials published between 2015 and 2019 were identified from six general and specialist high-impact factor medical journals. The review outcome was participant retention for each reviewed trial's primary outcome. Context (e.g. population, disease) and design (e.g. length of trial) factors were extracted. Retention was examined for each co

SUBMITTER: Gaunt DM 

PROVIDER: S-EPMC10265847 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature