Assessment of genetic polymorphisms associated with malaria antifolate resistance among the population of Libreville, Gabon.

ABSTRACT:

Background

Gabon is a malaria-threatened country with a stable and hyperendemic transmission of Plasmodium falciparum monoinfection. Malaria drug resistance is widely spread in many endemic countries around the world, including Gabon. The molecular surveillance of drug resistance to antifolates and artemisinin-based combination therapy (ACT) is one of the strategies for combating malaria. As Plasmodium parasites continue to develop resistance to currently available anti-malarial drugs, this study evaluated the frequency of the polymorphisms and genetic diversity associated with this phenomenon among the parasites isolates in Gabon.

Methods

To assess the spread of resistant haplotypes among the malaria-infected population of Libreville, single nucleotide polymorphisms linked

SUBMITTER: Dinzouna-Boutamba SD 

PROVIDER: S-EPMC10265907 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature