Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types.

ABSTRACT:

Background

Neuronal networks receive and deliver information to regulate bodily functions while the vascular network provides oxygen, nutrients, and signaling molecules to tissues. Neurovascular interactions are vital for both tissue development and maintaining homeostasis in adulthood; these two network systems align and reciprocally communicate with one another. Although communication between network systems has been acknowledged, the lack of relevant in vitro models has hindered research at the mechanistic level. For example, the current used in vitro neurovascular models are typically established to be short-term (≤ 7 days) culture models, and they miss the supporting vascular mural cells.

Methods

In this study, we utilized human induced pluripotent stem cell (hiPSC) -de

SUBMITTER: Isosaari L 

PROVIDER: S-EPMC10265920 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature