SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux.
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ABSTRACT:
SUBMITTER: Mozzi A
PROVIDER: S-EPMC10265927 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
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SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux.
Mozzi Alessandra A Oldani Monica M Forcella Matilde E ME Vantaggiato Chiara C Cappelletti Gioia G Pontremoli Chiara C Valenti Francesca F Forni Diego D Saresella Marina M Biasin Mara M Sironi Manuela M Fusi Paola P Cagliani Rachele R
iScience 20230614 7
Coronaviruses encode a variable number of accessory proteins that are involved in host-virus interaction, suppression of immune responses, or immune evasion. SARS-CoV-2 encodes at least twelve accessory proteins, whose roles during infection have been studied. Nevertheless, the role of the ORF3c accessory protein, an alternative open reading frame of ORF3a, has remained elusive. Herein, we show that the ORF3c protein has a mitochondrial localization and alters mitochondrial metabolism, inducing ...[more]
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