Newborn screen metabolic panels reflect the impact of common disorders of pregnancy.

ABSTRACT:

Background

Hypertensive disorders of pregnancy and maternal diabetes profoundly affect fetal and newborn growth, yet disturbances in intermediate metabolism and relevant mediators of fetal growth alterations remain poorly defined. We sought to determine whether there are distinct newborn screen metabolic patterns among newborns affected by maternal hypertensive disorders or diabetes in utero.

Methods

A retrospective observational study investigating distinct newborn screen metabolites in conjunction with data linked to birth and hospitalization records in the state of California between 2005 and 2010.

Results

A total of 41,333 maternal-infant dyads were included. Infants of diabetic mothers demonstrated associations with short-chain acylcarnitines and free carnitine.

SUBMITTER: Reiss JD 

PROVIDER: S-EPMC10265936 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature