Association of bone morphogenetic protein 10 and recurrent atrial fibrillation after catheter ablation.

ABSTRACT:

Aims

Atrial remodelling, defined as a change in atrial structure, promotes atrial fibrillation (AF). Bone morphogenetic protein 10 (BMP10) is an atrial-specific biomarker released to blood during atrial development and structural changes. We aimed to validate whether BMP10 is associated with AF recurrence after catheter ablation (CA) in a large cohort of patients.

Methods and results

We measured baseline BMP10 plasma concentrations in AF patients who underwent a first elective CA in the prospective Swiss-AF-PVI cohort study. The primary outcome was AF recurrence lasting longer than 30 s during a follow-up of 12 months. We constructed multivariable Cox proportional hazard models to determine the association of BMP10 and AF recurrence. A total of 1112 patients with AF (age 61

SUBMITTER: Hennings E 

PROVIDER: S-EPMC10265951 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature