The protein methylation network in yeast: A landmark in completeness for a eukaryotic post-translational modification.

ABSTRACT: Defining all sites for a post-translational modification in the cell, and identifying their upstream modifying enzymes, is essential for a complete understanding of a modification's function. However, the complete mapping of a modification in the proteome and definition of its associated enzyme-substrate network is rarely achieved. Here, we present the protein methylation network for Saccharomyces cerevisiae. Through a formal process of defining and quantifying all potential sources of incompleteness, for both the methylation sites in the proteome and also protein methyltransferases, we prove that this protein methylation network is now near-complete. It contains 33 methylated proteins and 28 methyltransferases, comprising 44 enzyme-substrate relationships, and a predicted further t

SUBMITTER: Hamey JJ 

PROVIDER: S-EPMC10265986 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature