Transcriptomics reveals a distinct metabolic profile in T cells from severe allergic asthmatic patients.

ABSTRACT: The reasons behind the onset and continuation of chronic inflammation in individuals with severe allergies are still not understood. Earlier findings indicated that there is a connection between severe allergic inflammation, systemic metabolic alterations and impairment of regulatory functions. Here, we aimed to identify transcriptomic alterations in T cells associated with the degree of severity in allergic asthmatic patients. T cells were isolated from severe (n = 7) and mild (n = 9) allergic asthmatic patients, and control (non-allergic, non-asthmatic healthy) subjects (n = 8) to perform RNA analysis by Affymetrix gene expression. Compromised biological pathways in the severe phenotype were identified using significant transcripts. T cells' transcriptome of severe a

SUBMITTER: Pablo-Torres C 

PROVIDER: S-EPMC10265992 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature