Association of IL-4 and IL-18 genetic polymorphisms with atopic dermatitis in Chinese children.

ABSTRACT:

Background

Atopic dermatitis (AD) is a common chronic inflammatory skin disease, adversely affecting nearly 20% of the pediatric population worldwide. Interleukin-4 (IL-4) and interleukin-18 (IL-18) are considered to be involved in the pathogenesis and development of AD. The aim of this study was to investigate the association of IL-4 and IL-18 gene polymorphisms with the susceptibility and severity of AD in Chinese children.

Methods

Six candidate single nucleotide polymorphisms (SNPs) in IL-4 and IL-18 genes were genotyped through multi-PCR combined with next-generation sequencing in 132 AD children and 100 healthy controls, and all the analyses were performed on blood genome DNA.

Results

The frequencies of G allele, CG genotype and CG + G

SUBMITTER: Shi J 

PROVIDER: S-EPMC10266202 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature