Efficacy of COVID-19 mRNA vaccination in patients with autoimmune disorders: humoral and cellular immune response.

ABSTRACT:

Background

The impact of immunosuppressive therapies on the efficacy of vaccines to SARS-CoV-2 is not completely clarified. We analyzed humoral and T cell-mediated response after COVID-19 mRNA vaccine in immunosuppressed patients and patients with common variable immunodeficiency disease (CVID).

Patients

We enrolled 38 patients and 11 healthy sex- and age-matched controls (HC). Four patients were affected by CVID and 34 by chronic rheumatic diseases (RDs). All patients with RDs were treated by corticosteroid therapy and/or immunosuppressive treatment and/or biological drugs: 14 patients were treated with abatacept, 10 with rituximab, and 10 with tocilizumab.

Methods

Total antibody titer to SARS-CoV-2 spike protein was assessed by electrochemiluminescence immunoassay,

SUBMITTER: Filippini F 

PROVIDER: S-EPMC10266318 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature