The role of inflammatory biomarkers in the development and progression of pre-eclampsia: a systematic review and meta-analysis.

ABSTRACT:

Background

Pre-eclampsia (PE) is a pregnancy complication associated with maternal and fetal morbidity and mortality. Among the potential pathogenesis discussed, inflammation is considered an essential initiator of PE. Previous studies have compared the levels of various inflammatory biomarkers that indicate the existence of PE; however, the relative levels of pro-inflammatory and anti-inflammatory biomarkers and their dynamic changes during PE progression remain unclear. This knowledge is essential to explain the occurrence and progression of the disease.

Objective

We aimed to identify the relationship between inflammatory status and PE using inflammatory biomarkers as indicators. We also discussed the underlying mechanism by which inflammatory imbalance contributes to PE b

SUBMITTER: Guan X 

PROVIDER: S-EPMC10266420 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature