Photocycle of a cyanobacteriochrome: a charge defect on ring C impairs conjugation in chromophore.

ABSTRACT: A large number of novel phytochromes named cyanobacteriochromes (CBCRs) have been recently identified. CBCRs appear to be attractive for further in-depth studies as paradigms for phytochromes because of their related photochemistry, but simpler domain architecture. Elucidating the mechanisms of spectral tuning for the bilin chromophore down to the molecular/atomic level is a prerequisite to design fine-tuned photoswitches for optogenetics. Several explanations for the blue shift during photoproduct formation associated with the red/green CBCRs represented by Slr1393g3 have been developed. There are, however, only sparse mechanistic data concerning the factors controlling stepwise absorbance changes along the reaction pathways from the dark state to the photoproduct and vice versa in

SUBMITTER: Kohler L 

PROVIDER: S-EPMC10266455 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature