The association between inflammatory markers in blood and cerebrospinal fluid: a systematic review and meta-analysis.

ABSTRACT:

Background

Neuroinflammatory processes have been hypothesized to play a role in the pathogenesis of psychiatric and neurological diseases. Studies on this topic often rely on analysis of inflammatory biomarkers in peripheral blood. Unfortunately, the extent to which these peripheral markers reflect inflammatory processes in the central nervous system (CNS) is unclear.

Methods

We performed a systematic review and found 29 studies examining the association between inflammatory marker levels in blood and cerebrospinal (CSF) samples. We performed a random effects meta-analysis of 21 studies (pooled n = 1679 paired samples) that reported the correlation of inflammatory markers in paired blood-CSF samples.

Results

A qualitative review revealed moderate to high quality of in

SUBMITTER: Gigase FAJ 

PROVIDER: S-EPMC10266485 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature