Ontology highlight
ABSTRACT:
SUBMITTER: Patel AJ
PROVIDER: S-EPMC10266577 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Patel Akshay J AJ Middleton Gary W GW
Immunotherapy advances 20230526 1
In this review, we explore the biology of the TIGIT checkpoint and its potential as a therapeutic target in lung cancer. We briefly review a highly selected set of clinical trials that have reported or are currently recruiting in non-small cell and small cell lung cancer, a disease transformed by the advent of PD-1/PD-L1 checkpoint blockade immunotherapy. We explore the murine data underlying TIGIT blockade and further explore the reliance of effective anti-TIGIT therapy on DNAM-1(CD226)-positiv ...[more]