Measures of Information Content during Anesthesia and Emergence in the Caenorhabditis elegans Nervous System.

ABSTRACT:

Background

Suppression of behavioral and physical responses defines the anesthetized state. This is accompanied, in humans, by characteristic changes in electroencephalogram patterns. However, these measures reveal little about the neuron or circuit-level physiologic action of anesthetics nor how information is trafficked between neurons. This study assessed whether entropy-based metrics can differentiate between the awake and anesthetized state in Caenorhabditis elegans and characterize emergence from anesthesia at the level of interneuronal communication.

Methods

Volumetric fluorescence imaging measured neuronal activity across a large portion of the C. elegans nervous system at cellular resolution during distinct states of isoflurane anesthesia, as well as during emergenc

SUBMITTER: Chang AS 

PROVIDER: S-EPMC10266588 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature