A Bayesian approach to estimate the probability of resistance to bedaquiline in the presence of a genomic variant.

ABSTRACT:

Background

Bedaquiline is a core drug for treatment of rifampicin-resistant tuberculosis. Few genomic variants have been statistically associated with bedaquiline resistance. Alternative approaches for determining the genotypic-phenotypic association are needed to guide clinical care.

Methods

Using published phenotype data for variants in Rv0678, atpE, pepQ and Rv1979c genes in 756 Mycobacterium tuberculosis isolates and survey data of the opinion of 33 experts, we applied Bayesian methods to estimate the posterior probability of bedaquiline resistance and corresponding 95% credible intervals.

Results

Experts agreed on the role of Rv0678, and atpE, were uncertain about the role of pepQ and Rv1979c variants and overestimated the probability of bedaquiline resistance fo

SUBMITTER: Anlay DZ 

PROVIDER: S-EPMC10266631 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature