High frequency of Voltage-gated sodium channel (VGSC) gene mutations in Aedes albopictus (Diptera: Culicidae) suggest rapid insecticide resistance evolution in Shanghai, China.

ABSTRACT:

Background

Dengue fever is an infectious disease that is imported into Shanghai, China and requires prevention and control measures. Controlling the vector Aedes albopictus through insecticide use is a key approach to dengue control. However, the rapid evolution of insecticide resistance in Ae. albopictus has raised concerns about the failure of dengue control efforts. Knockdown resistance (kdr) caused by point mutations in the voltage-gated sodium channel (VGSC) gene is a primary mechanism of pyrethroid resistance. In this study, we investigated the kdr mutations of Ae. albopictus in Shanghai and evaluated the trend in its evolution.

Methodology/principal findings

We collected 17 populations of Ae. albopictus from 15 districts in Shanghai in 2020, extracted genomic DNA from

SUBMITTER: Yuan H 

PROVIDER: S-EPMC10266648 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature