Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expression.

ABSTRACT: Correct notochord and neural tube (NT) formation is crucial to the development of the central nervous system and midline structures. Integrated biochemical and biophysical signaling controls embryonic growth and patterning; however, the underlying mechanisms remain poorly understood. Here, we took the opportunities of marked morphological changes during notochord and NT formation and identified both necessary and sufficient roles of Yap, a key mechanosensor and mechanotransducer, in biochemical signaling activation during formation of notochord and floor plate, the ventral signaling centers that pattern the dorsal-ventral axis of NT and the surrounding tissues. We showed that Yap activation by a gradient of mechanical stress and tissue stiffness in the notochord and ventral NT induces F

SUBMITTER: Cheng C 

PROVIDER: S-EPMC10266736 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature