Intravenous and oral whole body ketone dosimetry, biodistribution, metabolite correction and kinetics studied by (R)-[1-¹¹C]β-hydroxybutyrate ([¹¹C]OHB) PET in healthy humans.

ABSTRACT:

Background

Ketones are increasingly recognized as an important and possibly oxygen sparing source of energy in vital organs such as the heart, the brain and the kidneys. Drug treatments, dietary regimens and oral ketone drinks designed to deliver ketones for organ and tissue energy production have therefore gained popularity. However, whether ingested ketones are taken up by various extra-cerebral tissues and to what extent is still largely unexplored. It was therefore the aim of this study to use positron emission tomography (PET) to explore the whole body dosimetry, biodistribution and kinetics of the ketone tracer (R)-[1-¹¹C]β-hydroxybutyrate ([¹¹C]OHB). Six healthy subjects (3 women and 3 men) underwent dynamic PET studies after both intravenous (90 min) a

SUBMITTER: Luong TV 

PROVIDER: S-EPMC10267081 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature