A polyamine acetyltransferase regulates the motility and biofilm formation of Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is a nosocomial pathogen highly resistant to environmental changes and antimicrobial treatments. Regulation of cellular motility and biofilm formation is important for its virulence, although it is poorly described at the molecular level. It has been previously reported that Acinetobacter genus specifically produces a small positively charged metabolite, polyamine 1,3-diaminopropane, that has been associated with cell motility and virulence. Here we show that A. baumannii encodes novel acetyltransferase, Dpa, that acetylates 1,3-diaminopropane, directly affecting the bacterium motility. Expression of dpa increases in bacteria that form pellicle and adhere to eukaryotic cells as compared to planktonic bacterial cells, suggesting that cell motility is linked to the po

SUBMITTER: Armalyte J 

PROVIDER: S-EPMC10267138 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature