Arylcarboxylation of unactivated alkenes with CO₂ via visible-light photoredox catalysis.

ABSTRACT: Photocatalytic carboxylation of alkenes with CO₂ is a promising and sustainable strategy to synthesize high value-added carboxylic acids. However, it is challenging and rarely investigated for unactivated alkenes due to their low reactivities. Herein, we report a visible-light photoredox-catalyzed arylcarboxylation of unactivated alkenes with CO₂, delivering a variety of tetrahydronaphthalen-1-ylacetic acids, indan-1-ylacetic acids, indolin-3-ylacetic acids, chroman-4-ylacetic acids and thiochroman-4-ylacetic acids in moderate-to-good yields. This reaction features high chemo- and regio-selectivities, mild reaction conditions (1 atm, room temperature), broad substrate scope, good functional group compatibility, easy scalability and facile derivatization of products. M

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10267151 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature