Reduced vmPFC-insula functional connectivity in generalized anxiety disorder: a Bayesian confirmation study.

ABSTRACT: Differences in the correlated activity of networked brain regions have been reported in individuals with generalized anxiety disorder (GAD) but an overreliance on null-hypothesis significance testing (NHST) limits the identification of disorder-relevant relationships. In this preregistered study, we applied both a Bayesian statistical framework and NHST to the analysis of resting-state fMRI scans from females with GAD and matched healthy comparison females. Eleven a-priori hypotheses about functional connectivity (FC) were evaluated using Bayesian (multilevel model) and frequentist (t-test) inference. Reduced FC between the ventromedial prefrontal cortex (vmPFC) and the posterior-mid insula (PMI) was confirmed by both statistical approaches and was associated with anxiety sensitivity. FC b

SUBMITTER: Steinhauser JL 

PROVIDER: S-EPMC10267153 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature