Circulating proteins and peripheral artery disease risk: observational and Mendelian randomization analyses.

ABSTRACT:

Aims

We conducted observational and Mendelian randomization (MR) analyses to explore the associations between blood proteins and risk of peripheral artery disease (PAD).

Methods and results

The observational cohort analyses included data on 257 proteins estimated in fasting blood samples from 12 136 Swedish adults aged 55-94 years who were followed up for incident PAD via the Swedish Patient Register. Mendelian randomization analyses were undertaken using cis-genetic variants strongly associated with the proteins as instrumental variables and genetic association summary statistic data for PAD from the FinnGen study (11 924 cases and 288 638 controls) and the Million Veteran Program (31 307 cases and 211 753 controls). The observational analysis, including 86 individua

SUBMITTER: Yuan S 

PROVIDER: S-EPMC10267302 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature