Performance of SNP barcodes to determine genetic diversity and population structure of Plasmodium falciparum in Africa.

ABSTRACT: Panels of informative biallelic single nucleotide polymorphisms (SNPs) have been proposed to be an economical method to fast-track the population genetic analysis of Plasmodium falciparum in malaria-endemic areas. Whilst used successfully in low-transmission areas where infections are monoclonal and highly related, we present the first study to evaluate the performance of these 24- and 96-SNP molecular barcodes in African countries, characterised by moderate-to-high transmission, where multiclonal infections are prevalent. For SNP barcodes it is generally recommended that the SNPs chosen i) are biallelic, ii) have a minor allele frequency greater than 0.10, and iii) are independently segregating, to minimise bias in the analysis of genetic diversity and population structure. Further

SUBMITTER: Argyropoulos DC 

PROVIDER: S-EPMC10267394 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature