Integrated metabolic and genetic analysis reveals distinct features of human differentiated thyroid cancer.

ABSTRACT:

Background

Differentiated thyroid cancer (DTC) affects thousands of lives worldwide each year. Typically, DTC is a treatable disease with a good prognosis. Yet, some patients are subjected to partial or total thyroidectomy and radioiodine therapy to prevent local disease recurrence and metastasis. Unfortunately, thyroidectomy and/or radioiodine therapy often worsen(s) quality of life and might be unnecessary in indolent DTC cases. On the other hand, the lack of biomarkers indicating a potential metastatic thyroid cancer imposes an additional challenge to managing and treating patients with this disease.

Aim

The presented clinical setting highlights the unmet need for a precise molecular diagnosis of DTC and potential metastatic disease, which should dictate appropriate thera

SUBMITTER: Cararo Lopes E 

PROVIDER: S-EPMC10267429 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature