Nuclear Factor-κB Clinical Significance in Breast Cancer: An Immunohistochemical Study.

ABSTRACT:

Objectives

Nuclear factor κB (NF-κB) is a superfamily of transcription factors that plays a key role in cancer genesis and progression. The present study aimed to examine the expression of NF-κB/p65 in breast cancer and its relationship with prognostic markers such as tumour grade, tumour size, hormone receptors, and HER-2.

Methods

Ninety-nine unselected formalin-fixed paraffin-embedded invasive ductal and lobular tissue sections were evaluated by immunohistochemistry methods to measure the expression of NF-κB/p65, oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), and Ki-67. We assessed the correlation between NF-κB/p65 and clinicopathological parameters.

Results

NF-κB/p65 was found only in the cytoplasm and positiv

SUBMITTER: Al-Mutairi MS 

PROVIDER: S-EPMC10267497 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature